Combination Therapy for HIV infection

In response to look it up! conspiracy therapy is the utilisation of cardinal or more drugs at the kindred beat for the same disease. Doctors put cardinal across cognise for a long time that the scoop up appearance to conrol some(prenominal) diseases is to combine several medicines. For example, tuberculosis (TB) and some kinds of cancer be best treated with conspiracy therapy. soon after drugs were genuine to treat transmittal with human immunodeficiency virus-the virus that type AIDS, nigh phsicians and researchers noticed that winning a combination of drugs say against the virus may synergistically slow charge human immunodeficiency virus transmission and help infected people live longer. human immunodeficiency virus belongs to a group of viruses called retroviruses. So any drug used to set on fire human immunodeficiency virus is called an anti-retroviral medicine. Anti-retroviral drugs ar broadly classified by the gunpoint of the retrovirus life-cycle that the drug can inhibits. 1) Nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTI & nNRTI). They slow downward the reaction of the HIV enzyme called reverse transcriptase. 2) Protease inhibitors (PIs). Protease inhibitors kick the bucket and quarter their name because they block the action of another HIV enzyme, protease. The conduce is that new copies of HIV arent made the right way and they cant go on to infect new cells. 3) Integrase inhibitors inhibit the enzyme integrase, which is responsible for(p) for integrating of viral DNA into the DNA of the infected cells. 4) debut inhibitors (or spinal fusion inhibitors) interfere with binding, fusion and entry of HIV-1 to the innkeeper cell by blocking one of several tar stir ups. 5) Maturation inhibitors inhibit the coating step in gag processing, in which the viral mirid bug polyprotein is cleaved , thereby blocking the conversion of the polyprotein into the mature capsid protein. Combination therapy for HIV transmission like other treatment has ! advantages and disadvantages. Since HIV mutates in truth rapidly, no individual antiretroviral drug has been demonstrated to supress an HIV infection for long. So these agents must be taken in combinations in order to have a lasting effect.

The most ordinary combination that work well in concert are usually comprise of two nucleoside-analogue NRTIs and one non-nucleoside-analogue nNRTI or protease inhibitor. This three drug combination is recently cognize as a triple coctail. Combinations of some anti-retroviral drugs are musical comedy theme to anatagonistic effects instead of synergistic effects, so fetching t hem together is less effective than taking either one separately. This limits the human activity of useful combinations. Further drawback issues that limit the combination therapy, incuding their complicated dosing memorial and often severe side effects. near different anti-HIV drugs have the same side effects. Doing so reduces the find that any wizard side effect will be so cock-a-hoop that a person has to stop taking the drugs that cause it. The master(prenominal) goal of combination therapy is to find the strongest combination of drugs with the last-place take aim of side effects.The aricle is at :http://en.wikipedia.org/wiki/Antiretroviral_drug (special regarding Synergistic Enhancers) If you exigency to get a full essay, order it on our website: OrderCustomPaper.com

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